AANEM News Express Related to Science News

AANEM News Express

Science News: Nerve Ultrasound Normal Values - Readjustment of the Ultrasound Pattern Sum Score UPSS

    12/6/2018
Submitted by: Elliot Bodofsky, MD
Edited by: Rocio Carolina Garcia Santibanez, MD


The News Science Editorial Board has chosen to highlight this article because ultrasound of nerves and muscles is a rapidly expanding area, leading to improvements in diagnosis of nerve and muscle disease. Reliable normal values, adjusted for gender, age, height and weight as appropriate are crucial. 

Science News: Female Dystrophinopathy: Review of the Current Literature

    11/13/2018
Submitted by Benn E. Smith, MD, News Science Editorial Board
Edited by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board


Those who care for muscular dystrophy patients will find this article – Female Dystrophinopathy: A Review of the Current Literature – a valuable resource as they continue to care for not only the more common population of boys and young men with Duchenne muscular dystrophy, but also for their sisters, mothers, and other female relatives.

Science News: Eteplirsen Treatment for Duchenne Muscular Dystrophy: Exon Skipping and Dystrophin Production

    10/30/2018
Submitted and edited by Leigh Maria K. Ramos-Platt, MD

While questions remain regarding whether increased dystrophin expression results in increased strength, this study demonstrates that Eteplirsen increases dystrophin production.

Science News: Anti-HMGCR Myopathy

    10/16/2018
Submitted by Benn E. Smith, MD, News Science Editorial Board
Edited by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board


This paper provides a succinct overview of anti-HMGCR myopathy, a readily diagnosable autoimmune necrotizing myopathy which can mimic LGMD.

Science News: Individualized Immunoglobulin Therapy in Chronic Immune-Mediated Peripheral Neuropathies

    10/2/2018
Submitted by Benn E. Smith, MD, News Science Editorial Board
Edited by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board


This article is recommended by the AANEM News Science Editorial Board due to its clear presentation of IVIg immunology, biology, and pharmacokinetics. It discusses the well-known “wearing off” phenomenon as well as a recommended algorithm to be used to adjust frequency and dose adjustments. 

Science News: Muscular and Extramuscular Clinical Features of Patients with Anti-PM/Scl Autoantibodies

    9/18/2018
Submitted by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board
Edited by Benn E. Smith, MD, News Science Editorial Board


This study focuses on whether there were features which set anti-PM/Scl autoantibody positive myositis patients apart from those patients with the 3 most common myositis (Dermatomyositis, Antisynthetase Syndrome, and Immune Mediated Necrotizing Myopathy). Using data from the John Hopkins Myositis Center Longitudinal Cohort collected between 2002 and 2016, various clinical and diagnostic study parameters found that there were differences which set these patients apart. 

Science News: Safety and Efficacy of Eculizumab in Guillain-Barré Syndrome: A Multicentre, Double-blind, Randomised Phase 2 Trial

    9/5/2018
Submitted by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board
Edited by Benn E. Smith, MD, News Science Editorial Board


Eculizumab is an anti-C5 humanized monoclonal antibody. Misawa et al report on a 34 patient, 24-week double-blind, randomized phase 2 study comparing IVIG and 4 weeks of eculizumab (900 mg per dose) versus IVIG and 4 weeks of placebo.

Science News - Muscle MRI in Patients with Dysferlinopathy: Pattern Recognition and Implications for Clinical Trials

    8/22/2018
Submitted by Francisco E. Gomez, MD, News Science Editorial Board 
Edited by Benn E. Smith, MD, News Science Editorial Board


This article summarizes a research paper in which the authors sought to describe the pattern and natural history of muscle involvement in patients with dysferlinopathies via MRI studies. 

Science News: Three Article Summaries on Recent Amyotrophic Lateral Sclerosis (ALS) Research Findings

    8/8/2018
The AANEM News Science Editorial Board provides summaries of recent research articles related to ALS.
  • Serum neurofilament light chain levels as a marker of upper motor neuron degeneration in patients with amyotrophic lateral sclerosis.
  • Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis
  • Electromyography study of the thoracic paraspinal and rectus abdominis muscles in amyotrophic lateral sclerosis

Science News: Ultrasonography of the Transverse Movement and Deformation of the Median Nerve and its Relationships with Electrophysiological Severity in the Early Stages of Carpal Tunnel Syndrome

    6/20/2018
Submitted by Lisa M. Williams, MD, News Science Editorial Board

To date, conflicting theories behind the initial pathogenic mechanism of carpal tunnel syndrome (CTS) exist. Recently, researchers have investigated the transverse plane movement of the median nerve as a potential mechanism for CTS. Using ultrasonography, the researchers of this study designed a cross-sectional, case-controlled study measuring deformation and displacement of the median nerve as it related to severity of CTS confirmed by electrophysiological studies. 


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