AANEM News Express Related to  NSEB

AANEM News Express

Science News: Clinical Value of Cell-Based Assays in the Characterisation of Seronegative Myasthenia Gravis

Although autoantibody testing is critical for the diagnosis of myasthenia gravis (MG) in current clinical practice, the test can be negative in up to 10% of cases of generalized MG and up to 50% of cases of ocular MG.

Latest Anthology of Articles from the News Science Editorial Board Now Available

Each year, AANEM's News Science Editorial Board (NSEB) scours 40+ journals and write summaries of articles they find of value to them and other AANEM members. At the end of the year, they are compiled into a downloadable PDF for your convienience.

Science News: Relative Sit-to-Stand Muscle Power Predicts an Older Adult's Physical Independence at Age of 90 Yrs Beyond That of Relative Handgrip Strength, Physical Activity, and Sedentary Time: A Cross-sectional Analysis

Functional decline associated with advanced age results in significant morbidity and mortality, in addition to increased demand on healthcare systems. Models and testing to predict functional decline help healthcare systems direct resources to vulnerable individuals that are at risk of future loss of independence.

Science News: Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial

There has been growing evidence that patients with myasthenia gravis (MG) can benefit from Rituximab therapy, particularly patients with refractory disease or MuSK antibody positive MG. However, there is no standardized protocol and hence it is a third-line treatment option in AChR antibody positive MG.

Science News: Ultrasound of Cervical Nerve Root Enlargement in Polyneuropathy is not Confounded by Neuroforaminal Stenosis

In this study, the authors aimed to investigate whether neuroforaminal cervical stenosis is associated with cervical root enlargements detectable by ultrasound.

Science News: Amyotrophic Lateral Sclerosis and Noninvasive Positive Pressure Ventilatory Support: "Nasal Noninvasive Ventilation" or "Noninvasive Ventilatory Support"?

This article proposes a trial of noninvasive ventilatory support as an alternative to tracheostomy in patients with amyotrophic lateral sclerosis (ALS). Studies have shown brief statistical benefit of nasal noninvasive ventilation; however, this strategy may not be able to normalize carbon dioxide (CO2), leading to hypercapnia and therefore eventually to CO2 narcosis, intubation, and tracheostomy.

Science News: Extensor Digitorum Brevis Bulk and Associations With Fibular Motor Nerve Conduction Amplitude

Prior studies demonstrate fibular compound motor action potential (CMAP) < 4.0 mV predicts impairment of ankle proprioceptive precision and increased fall risk. The authors posit that evaluation of extensor digitorum brevis (EDB) may present a simple surrogate for CMAP amplitude. This study aims to correlate physician evaluation of EDB muscle bulk with CMAP amplitude on nerve conduction study (NCS).

Science News: Eculizumab Versus Rituximab in Generalised Myasthenia Gravis

A small sub-group of myasthenia gravis (MG) patients is refractory to first-line immunosuppressive medications. Complement-targeted therapies are relatively new in neurological practice but gaining grounds in the landscape of MG management, particularly acetylcholine receptor antibody (AChR)-Ab positive cases.

Science News: Measurement of Excitation-Contraction Coupling Time in Critical Illness Myopathy

This study describes a novel electrophysiological method using an accelerometer to measure the excitation-contraction coupling of the soleus muscle for early diagnosis of critical illness myopathy (CIM).

Science News: Physiological Localization by Sensory and Motor Inching Studies and Structural Abnormalities Detected by Ultrasonographic Changes in Carpal Tunnel Syndrome

This is a cross-sectional study that investigated carpal tunnel syndrome (CTS) to determine correlation of electrophysiologically localized entrapment site using inching study with anatomic entrapment site identified by ultrasound (US).