AANEM Education News Express

AANEM News Express

Science News: Placebo Effect in Chronic Inflammatory Demyelinating Polyneuropathy: The PATH Study and a Systematic Review

    1/20/2021
Placebos (pharmacologically inert preparations) are used in treatment trials to assess the true effect of trial medication. Placebo response have been noted in CIDP trials including the most recent PATH trial investigating subcutaneous IVIG as maintenance therapy.

Science News: An Appraisal of Electrodiagnostic Studies in Stiff Person Syndrome

    1/11/2021
This is a review of electrodiagnostic (EDX) findings for diagnosis of stiff person syndrome (SPS). The authors performed a literature review of EDX findings in SPS as well as an online survey of SPS among EDX labs accredited by the AANEM.

Science News: Utility of Nerve Conduction Studies and Ultrasonography in Ulnar Neuropathies at the Elbow of Different Severity

    11/24/2020
This study compared ultrasound (US), short segment nerve conduction studies (SSNCS), and 10 cm NCS across the elbow, for detection and localization of Ulnar nerve compression at the elbow (UNE).

Science News: Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

    11/11/2020
This is a retrospective analysis of 214 patients from WUHAN, China with COVID-19, 126 patients (58.9%)non severe infection, and 88 patients (41.1%) had severe infection according to respiratory status.

Science News: COVID-19 and Neuromuscular Disorders

    10/26/2020
Drs. Guidon and Amato provide a timely review of the COVID-19 pandemic's potential effects on patients with neuromuscular disorders. They cover the broad spectrum of how the pandemic affected the delivery of neuromuscular care to education and research.

Science News: ASC-1 is a Cell Cycle Regulator Associated With Severe and Mild Forms of Myopathy

    10/14/2020
Dysfunction of the transcriptional coactivator ASC-1 (activating signal cointegrator 1) complex has been demonstrated in forms of ALS, SMA, and congenital myopathies. Mutations in TRIP4 gene, which encodes ASC-1, has been described recently in a family with congenital myopathy.

Science News: A Model to Study Myelinated Fiber Degeneration and Regeneration in Human Skin

    9/30/2020
The authors sought to describe changes with degeneration and regeneration of large myelinated fibers and Meissner corpuscles (MC) in a cohort of patients with median nerve compression at the wrist, pre and post surgery.

Science News: Antibody and Macrophage-Mediated Segmental Demyelination in Chronic Inflammatory Demyelinating Polyneuropathy

    9/14/2020
Retrospective study of immune reactivity to myelin in 94 patients with diagnoses of chronic inflammatory demyelinating polyneuropathy (CIDP). Nerve biopsy was done for those who did not fulfill these criteria at first assessment.

Science News: Antidiabetics, Statins, and the Risk of Amyotrophic Lateral Sclerosis

    9/1/2020
Submitted by Nandita Keole, MD

Drugs used to treat glucose or lipid metabolism have been suggested as risk factors for ALS. Population based case control study ( 5 controls for each case of ALS) done in Sweden to examine the association between statins, antidiabetics, and subsequent development of ALS.

Science News: Ultrasound Guidance Increases Diagnostic Yield of Needle EMG in Plegic Muscle

    8/17/2020
Submitted by Elliot Bodofsky, MD
Edited by Francisco Gomez, MD


Major peripheral nerve injury is common and quite disabling, and the detection of early reinnervation is crucial in determining prognosis and treatment. Standard needle EMG involves random muscle needle insertion, and hence can miss minimal residual muscle activity.


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