AANEM Education News Express

AANEM News Express

Science News: ASC-1 is a Cell Cycle Regulator Associated With Severe and Mild Forms of Myopathy

    10/14/2020
Dysfunction of the transcriptional coactivator ASC-1 (activating signal cointegrator 1) complex has been demonstrated in forms of ALS, SMA, and congenital myopathies. Mutations in TRIP4 gene, which encodes ASC-1, has been described recently in a family with congenital myopathy.

Science News: A Model to Study Myelinated Fiber Degeneration and Regeneration in Human Skin

    9/30/2020
The authors sought to describe changes with degeneration and regeneration of large myelinated fibers and Meissner corpuscles (MC) in a cohort of patients with median nerve compression at the wrist, pre and post surgery.

Science News: Antibody and Macrophage-Mediated Segmental Demyelination in Chronic Inflammatory Demyelinating Polyneuropathy

    9/14/2020
Retrospective study of immune reactivity to myelin in 94 patients with diagnoses of chronic inflammatory demyelinating polyneuropathy (CIDP). Nerve biopsy was done for those who did not fulfill these criteria at first assessment.

Science News: Antidiabetics, Statins, and the Risk of Amyotrophic Lateral Sclerosis

    9/1/2020
Submitted by Nandita Keole, MD

Drugs used to treat glucose or lipid metabolism have been suggested as risk factors for ALS. Population based case control study ( 5 controls for each case of ALS) done in Sweden to examine the association between statins, antidiabetics, and subsequent development of ALS.

Science News: Ultrasound Guidance Increases Diagnostic Yield of Needle EMG in Plegic Muscle

    8/17/2020
Submitted by Elliot Bodofsky, MD
Edited by Francisco Gomez, MD


Major peripheral nerve injury is common and quite disabling, and the detection of early reinnervation is crucial in determining prognosis and treatment. Standard needle EMG involves random muscle needle insertion, and hence can miss minimal residual muscle activity.

Science News: A Model to Predict the Probability of Acute Inflammatory Demyelinating Polyneuropathy

    8/3/2020
Submitted by Elliot Bodofsky, MD
Edited by Hristelina Ilieva, MD, PhD


The goal of this research was developing a predictive model to differentiate acute inflammatory demyelinating polyneuropathy (AIDP) from non-demyelinating Guillain-Barré syndrome (GBS), based on NCSs performed at 1-20 days after onset and at 3-8 weeks.

Science News: Imaging of the Peripheral Nerve: Concepts and Future Direction of Magnetic Resonance Neurography and Ultrasound

    6/26/2020
Submitted by Rebecca O'Bryan, MD
Edited by Francisco Gomez, MD


This review article provides an overview of the most current concepts in peripheral nerve imaging in the context of nerve injury and compressive neuropathies. It goes into some detail with regards to the application of each modality (ultrasound and magnetic resonance neurography), and then provides direction about imaging choices based on the clinical picture.

Science News: Treadmill Training in Patients Affected by Charcot-Marie-Tooth Neuropathy: Results of a Multicenter, Prospective, Randomized, Single-blind, Controlled Study

    6/15/2020
Submitted by Nandita Keole, MD
Edited by Francisco Gomez, MD


A multicenter, prospective, randomized, single-blind, controlled study of 53 outpatients affected by CMT1A who were recruited and randomized in two treatment groups: one underwent stretching and proprioceptive exercise (SPE), whereas the other was additionally treated with treadmill training (TreSPE).

Registration for ABEM's 2020 Neuromuscular Ultrasound Certificate of Added Qualification (CAQ) Exam is Open

    6/9/2020
Neuromuscular Ultrasound Certificate of Added Qualification (CAQ) Exam registration is now available online.

Science News: Combined Intravenous Immunoglobulin and Methylprednisolone as Induction Treatment in Chronic Inflammatory Demyelinating Polyneuropathy (OPTIC protocol): A Prospective Pilot Study

    5/29/2020
Submitted by Nandita Keole, MD
Edited by Francisco Gomez, MD

 

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated neuropathy causing appendicular sensorimotor. Treatment of CIDP frequently consists of immunomodulation via IVIG or steroids, however an efficacious and cost-effective treatment regime has proven elusive. In this non-controlled open-label pilot study, which is to precede a randomized control trial, authors sought to test a combined IVIg and IV methylprednisolone (IVMP) regimen.



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