Science News: Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration
1/22/2018
Submitted by Shan (Sarah) Chen, MD, PhD, News Science Editorial Board
Edited by Nandita S. Keole, MD, News Science Editorial Board
This article summary provides details about a study on a commonly used chemotherapeutic agent, Paclitaxel, and how it triggers CIPN by altering IP3 receptor (IP3R1) phosphorylation and reducing synthesis of Bclw (a Bcl2 family member).