AANEM Education News Express

AANEM News Express

Science News: Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration

    1/22/2018
Submitted by Shan (Sarah) Chen, MD, PhD, News Science Editorial Board
Edited by Nandita S. Keole, MD, News Science Editorial Board

This article summary provides details about a study on a commonly used chemotherapeutic agent, Paclitaxel, and how it triggers CIPN by altering IP3 receptor (IP3R1) phosphorylation and reducing synthesis of Bclw (a Bcl2 family member).

Science News: Anti-MAG Antibodies in 202 Patients: Clinicopathological and Therapeutic Features

    1/15/2018

Submitted by Francisco E. Gomez, MD, News Science Editorial Board
Edited by Lisa M. Williams, MD, News Science Editorial Board
 

In this study, the authors characterize neuropathy arising from anti-myelin-associated-glycoprotein (anti-MAG) antibodies, as an IgM monoclonal gammopathy in order to assess the pathologic features and clinical management of anti-MAG associated neuropathies.


Science News: Safety Window for the Volar Needle Approach for Examination of the Pronator Quadratus Using Ultrasonography

    12/29/2017
Submitted by Lisa M. Williams, MD, News Science Editorial Board
Edited by Niranjan N. Singh, MD, News Science Editorial Board
 
In this study in Archives of Physical Medicine and Rehabilitation, the authors aim to investigate pronator quadratus (PQ) anatomy and determine the proper volar needle insertion using ultrasonography in 25 volunteers and 50 PQ samples.

Science News: Human Dorsal Root Ganglion in Vivo Morphometry and Perfusion in Fabry Painful Neuropathy

    12/26/2017
Submitted by David B. Rosenfield, MD, News Science Editorial Board
Edited by Niranjan N. Singh, MD, News Science Editorial Board
 
The News Science Editorial Board provides an article summary on a study published in Neurology which demonstrated unique dorsal root ganglia enlargement in patients with Fabry Disease and pain crisis.   

Science News: Polyneuropathy Relates to Impairment in Daily Activities, Worse Gait, and Fall-Related Injuries

    12/18/2017
Submitted by David B. Rosenfield, MD, News Science Editorial Board
Edited by Niranjan N. Singh, MD, News Science Editorial Board

A recent article from Neurology featured a population-based study in which activities of daily living were monitored in patients with polyneuropathy. 

Win an Award for Your Scientific Research!

    12/13/2017
Find out more about abstract awards you could win from the AANEM Foundation. Abstracts for 2018 will be accepted between January 1 and March 15, 2018.  

Science News: Tacrolimus Improves Symptoms of Children with Myasthenia Gravis Refractory to Prednisone

    12/13/2017
Submitted by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board
Edited by Niranjan N. Singh, MD, News Science Editorial Board


The latest article summary from the AANEM News Science Editorial Board covers an evaluation of the efficacy of Tacrolimus in Chinese pediatric autoimmune Myasthenia Gravis patients.

Science News: Chemotherapy-Induced Peripheral Neuropathy: A Current Review

    11/30/2017
Submitted by John C. Kincaid, MD, News Science Editorial Board
Edited by Niranjan N. Singh, MD, News Science Editorial Board

In the June 2017 edition of Annals of Neurology, Dr. Staff and his colleagues from Mayo Clinic in Rochester, Minnesota published a very detailed review article on chemotherapy-induced peripheral neuropathy (CIPN) which is a sensory predominant painful condition seen in 30-40 percent of patients receiving neurotoxic chemotherapy agents. In this review, they discuss the approach to peripheral neuropathy in patients with cancer and address the clinical phenotype and pathomechanism of specific neurotoxic chemotherapeutic agents and treatment options.
 

Science News: Rise of Biomarkers – Part 4

    11/27/2017
Submitted by Nandita Keole, MD, News Science Editorial Board  
Edited by Francisco Gomez, MD, News Science Editorial Board
 
In “Rise of the Biomarkers – Part 4” (final segment of the biomarker series), researchers analyze skin biopsies of patients with diabetes mellitus (with and without diabetic neuropathy) and make some important discoveries. 

Science News: Rise of Biomarkers – Part 3

    11/21/2017
Submitted and edited by Francisco Gomez, MD, News Science Editorial Board
 
In “Rise of the Biomarkers – Part 3” (of a four-part series), biomarkers for Charcot-Marie-Tooth disease 1A are discussed. 


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