AANEM News Express Related to Science News

AANEM News Express

Science News: Ultrasonography of the Transverse Movement and Deformation of the Median Nerve and its Relationships with Electrophysiological Severity in the Early Stages of Carpal Tunnel Syndrome

    6/20/2018
Submitted by Lisa M. Williams, MD, News Science Editorial Board

To date, conflicting theories behind the initial pathogenic mechanism of carpal tunnel syndrome (CTS) exist. Recently, researchers have investigated the transverse plane movement of the median nerve as a potential mechanism for CTS. Using ultrasonography, the researchers of this study designed a cross-sectional, case-controlled study measuring deformation and displacement of the median nerve as it related to severity of CTS confirmed by electrophysiological studies. 

Science News: Clustering of Neuropsychiatric Disease in First-degree and Second-degree Relatives of Patients with Amyotrophic Lateral Sclerosis

    6/13/2018
Submitted by Niranjan N. Singh, MD, News Science Editorial Board

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition primarily involving the motor system. There is increasing epidemiologic evidence of an association between ALS and a wider spectrum of neurodegenerative and neuropsychiatric disorders among family members, including schizophrenia and psychotic illness and suicidal behavior. In this issue of JAMA Neurology, O’Brien et al present a case-control family aggregation study of genetic pleiotropy within ALS kindreds.

Science News: Effect of Fascia Penetration on Sensory Nerve Conduction in the Superficial Radial Nerve

    6/7/2018
Submitted by Rocio Carolina Garcia Santibanez, MD, News Science Editorial Board

In this study, the investigators sought to determine the effect of the fascia penetration of the radial nerve in its sensory nerve action potential amplitude.

Science News: Motor Performance Deterioration Accelerates After 50 Years of Age in Charcot-Marie-Tooth Type 1A Patients

    5/31/2018
Submitted by Nandita S. Keole, MD, News Science Editorial Board

The aim of this study was to describe, by a case control and cross-sectional design, the correlation between clinical impairment and age in Charcot-Marie-Tooth type 1A (CMT1A) patients.

Science News - Diagnosis and Management of SMA Part 1: Recommendations for Diagnosis, Rehabilitation, Orthopedic, and Nutritional Care

    5/25/2018
Submitted by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board   
Additional comments by David B. Rosenfield, MD, News Science Editorial Board


In December 2016, the spinal muscular atrophy (SMA) community recognized the need for the SMA Standards of Care (SOC) document to be updated. Part 1 of the updated set of guidelines was recently published and this summary highlights those updates. 

Science News: Nusinersen Versus Sham Control in Later-onset Spinal Muscular Atrophy

    5/15/2018
Submitted by David R. Mayans, MD, News Science Editorial Board  
Additional comments by David B. Rosenfield, MD, News Science Editorial Board


This is another study adding to the growing body of evidence that Nusinersen is effective at not only slowing the progression of SMA, but leading to improvements in strength and gain of function in SMA patients. 

Science News: Associated Conditions in Small Fiber Neuropathy – A Large Cohort Study and Review of the Literature

    5/10/2018
Submitted by Nandita S. Keole, MD, News Science Editorial Board 
Additional comments by David B. Rosenfield, MD, News Science Editorial Board


Small fiber neuropathy (SFN) is a common disorder leading to neuropathic pain and autonomic symptoms. The objective of this study was to investigate associated conditions in a large cohort of SFN patients and compare the prevalence to healthy individuals. 

Science News: Brain-derived Neurotrophic Factor Derived from Sensory Neurons Plays a Critical Role in Chronic Pain

    5/3/2018
Submitted by Francisco E. Gomez, MD, News Science Editorial Board 
Additional comments by David B. Rosenfield, MD, News Science Editorial Board


In this ambitious study, investigators sought to determine the role of sensory neuron – brain-derived neurotrophic factor (BDNF) – in the genesis of chronic pain.

Science News: Immune or Genetic-mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability

    5/1/2018
Submitted by Shan (Sarah) Chen, MD, PhD, News Science Editorial Board
Additional comments by David B. Rosenfield, MD, News Science Editorial Board


In this article in Neuron, the authors discuss that contactin-associated protein-like 2 (CASPR2) antibodies cause loss of Kv1 channel membrane expression and hyperexcitability in Dorsal Root Ganglion (DRG) without preexisting nerve injury or inflammation. These authors demonstrate in mice that one can passively transfer an autoimmune peripheral neuropathic disorder in which CASPR2 has an important role in regulating DRG excitability and posit that these antibodies might even have a role in autism spectrum disorders.

Science News: Two Reports on Spinal Muscular Atrophy Treatments - Nusinersen and Gene Replacement Therapy

    3/26/2018
Recent articles in the New England Journal of Medicine provide insight into spinal muscular atrophy treatments involving Nusinersen and gene replacement therapy.


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