AANEM News Express Related to Science News

AANEM News Express

Randomized Trial of Thymectomy in Myasthenia Gravis

    11/2/2016
This study in the New England Journal of Medicine demonstrates a clear clinical benefit of thymectomy in patients with non-thymomatous myasthenia gravis

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

    9/21/2016
This study in Neuron identified gain of toxicity as a main pathogenesis of GGGGCC-expanded C9ORF72 for ALS/FTD, and also proved the feasibility and effectiveness of antisense oligonucleotides-mediated therapy. 

Idebenone Reduces Respiratory Complications In Patients with Duchenne Muscular Dystrophy

    8/24/2016
This study in Neuromuscular Disorders reports the effects of Idebenone in patients with Duchenne Muscular Dystrophy.

Science News: Identifying who will benefit from NIV in ALS

    8/10/2016
This retrospective study in the Journal of Neurology, Neurosurgery & Psychiatry bolsters the evidence to support non-invasive ventilation (NIV) prescription in patients with ALS.

Modulating Myosin Restores Muscle Function in a Mouse Model of Nemaline Myopathy

    7/27/2016
This study in the Annals of Neurology demonstrated increased myofiber size and force generation in myocytes of ACTA1 transgenic mice injected with the gene encoding the MyLC1a/emb isoform.

Dystrophinopathy Diagnosis: Skin Biopsy, an Emerging Novel Tool

    7/29/2014
In this study, 119 patients (111 boys and 8 girls) with suspected muscular dystrophy underwent both a skin biopsy (from the anterior thigh) and a gold standard confirmatory test. 

Backward Walking Therapy for Diabetic Peripheral Neuropathy

    7/16/2014
Diabetic peripheral neuropathy is a common and costly condition, often leading to significant morbidity, including pain and foot ulcerations. A new study investigates the use of backward walking therapy as a treatment tool for patients with diabetic peripheral neuropathy.

Early Investigation of Novel ALS Treatment

    7/1/2014
A new learning phase study investigates a novel potential treatment for amyotrophic lateral sclerosis (ALS), the antibody Ozanezumab. It appears to be reasonably safe and worth proceeding with additional study.

Clinical Interpretation and Implications of Whole-Genome Sequencing

    5/20/2014
This JAMA article raises several key concerns about the NM physician’s ability to support the costs and effort required for whole-genome sequencing.

Is IVIg Therapy Warranted in Progressive Lower Motor Neuron Syndromes Without Conduction Block?

    5/6/2014
Study reports results of treatment of 31 consecutive patients with focal-onset lower motor neuron pattern limb weakness with intravenous immunoglobulin (IVIg). None of the patients had EDX signs of a generalized motor neuron disorder or evidence of conduction block.


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