AANEM News Express Related to Science News

AANEM News Express

Science News: Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis

    1/23/2020
Submitted by Rebecca O'Bryan, MD
Edited by Clark Pinyan, MD


This article reports on the clinical significance of certain presentations of carpal tunnel syndrome as they relate to the potential earlier diagnosis of amyloidosis in patients with systemic disease. Due to the importance of diagnosing systemic amyloidosis (either light chain or transthyretin), a high index of suspicion is vital in identification and early treatment of these patients.

Science News: Degree of Agreement between Electrodiagnostic Testing and Magnetic Resonance Imaging in the Evaluation of Brachial Plexopathy

    1/9/2020
Submitted by Rebecca O'Bryan, MD
Edited by Clark Pinyan, MD


This article reports the findings of a retrospective analysis of 69 patients with symptoms of brachial plexopathy of various etiologies to investigate the degree of agreement between magnetic resonance imaging (MRI) and electrodiagnostic testing (EDX). Of the 69 patients reviewed, 12 were excluded due to diagnoses of other diseases during the assessment, or due to lack of evidence to support the diagnosis on either test (EDX or MRI).

Science News: Muscle and Not Neuronal Biomarkers Correlate With Severity in Spinal and Bulbar Muscular Atrophy

    12/12/2019
Submitted by Bryan X. DeSouza, MD
Edited by Elliot Bodofsky, MD

This study examined longitudinal changes in neuronal and muscular serum biomarkers (neurofilament light chain [NfL], creatinine kinase [CK] and creatinine) in spinal and bulbar muscular atrophy (SBMA, also known as Kennedy's disease - KD) and correlated their findings to clinical measures of disease severity in patients and a mouse model.


Science News: Inhibition of Natriuretic Peptide Receptor 1 Reduces Itch in Mice

    11/26/2019
Submitted by Hristelina Ilieva, MD, PhD
Edited by Elliot Bodofsky, MD


Neuromuscular specialists see a variety of neuropathies, particularly uremic neuropathy patients, with very frequent complaints of itching. Being aware of the neurophysiology and that future therapeutic targets exist will be helpful.

Science News: Schwann Cell Transcript Biomarkers For Hereditary Neuropathy Skin Biopsies

    10/22/2019
Submitted by Clark Pinyan, MD
Edited by Nandita Keole, MD


This article strives to help the reader understand the expanding potential of skin biopsy. As treatments emerge for CMT, skin biopsy may prove a useful marker for treatment response or disease progression.

Science News: Smoking and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study

    10/4/2019
Submitted by Clark Pinyan, MD
Edited by Nandita Keole, MD


Authors examined the potential causal effect of smoking on ALS using Mendelian randomization method. Genome-wide association study data was reviewed for loci associated with smoking (current or ever smoked).

Science News: Compound Muscle Action Potential Amplitude Predicts the Severity of Cubital Tunnel Syndrome

    9/18/2019
Submitted by Elliot Bodofsky, MD
Edited by Nandita Keole, MD


This article suggests a different parameter is useful for determining Cubital Tunnel Syndrome severity. It helps in clarifying the arguments for using First Dorsal Interosseous amplitude to assess Cubital Tunnel Syndrome severity. 

Science News: Role of Ultrasonography in Severe Distal Median Nerve Neuropathy

    9/9/2019
Submitted by Rocio (Carolina) Garcia Santibanez, MD
Edited by Lisa Williams, MD


This study looked at the use of ultrasound in 46 patients with clinical and electrophysiologic evidence of severe carpal tunnel syndrome (CTS). Patients with peripheral neuropathy and a history of carpal tunnel surgery were excluded.

Science News: Shared Polygenic Risk and Causal Inferences in Amyotrophic Lateral Sclerosis

    8/28/2019
Submitted by Clark Pinyan, MD, MPH
Edited by Lisa Williams, MD


In this no-hypothesis exploratory study, there is some genetic confirmation of epidemiologically suggested risks for ALS including smoking, lower education and hyperlipidemia, though the traditional epidemiological studies for low-density lipoprotein and ALS are somewhat mixed.

Science News: Efficacy of Botulinum Toxin A for Treating Cramps in Diabetic Neuropathy

    7/1/2019
Submitted by: Clark W. Pinyan, MD, MPH
Edited by: T. Darrell Thomas, MD


Botulinum toxin injections are already useful in a variety of clinical conditions with cramps and spasms such as multiple sclerosis or lumbar spinal stenosis. This article studies the use of Botulinum Toxin A for treating cramps in patients with diabetic neuropathy. This could be an emerging tool used for patients who are often refractory to other therapies.


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