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AANEM News Express

Science News: Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy

In this single-centered study, 113 anti-NF155 and anti-CNTN1 antibody–negative chronic inflammatory demyelinating polyneuropathy (CIDP) patients were enrolled and the reactivity of sera from these patients against mouse (dorsal root ganglion) DRG and sciatic nerves was surveyed. The objective of this was to identify novel nodal autoantibodies in CIDP.

Science News: Anti-titin Antibody Is Associated With More Frequent Hospitalization to Manage Thymoma-Associated Myasthenia Gravis

Anti-titin antibodies are anti-striational antibodies associated with thymoma-associated myasthenia gravis (MG). Anti-titin antibodies have been previously linked to severity of MG, but its relation to clinical worsening is not clear. Thus, the authors in this study aimed to evaluate whether the patients with anti-titin antibody are more frequently hospitalized to manage thymoma-associated MG than those patients without anti-titin antibody.

Science News: Virtual Charcot-Marie-Tooth Examination Score: A Validated Virtual Evaluation for People with Charcot-Marie-Tooth Disease.

The Charcot-Marie-Tooth (CMT) Examination Score Version 2 (CMTESv2) is used in clinical practice to measure impairment in patients with CMT. However, the CMTES requires an in-person visit, which may not be possible for all CMT patients. This study evaluated a virtual form of CMTES (vCMTES) as a remote clinical outcome assessment tool to measure impairment in CMT patients.

Science News: Ultrasonographic Prevalence of Ulnar Nerve Displacement at the Elbow in Young Baseball Players

Studies regarding ulnar nerve damage/displacement have been performed primarily in adults. The authors of this study assessed the ulnar nerve displacement in young baseball players.

Science News: Clinical Value of Cell-Based Assays in the Characterisation of Seronegative Myasthenia Gravis

Although autoantibody testing is critical for the diagnosis of myasthenia gravis (MG) in current clinical practice, the test can be negative in up to 10% of cases of generalized MG and up to 50% of cases of ocular MG.

Latest Anthology of Articles from the News Science Editorial Board Now Available

Each year, AANEM's News Science Editorial Board (NSEB) scours 40+ journals and write summaries of articles they find of value to them and other AANEM members. At the end of the year, they are compiled into a downloadable PDF for your convienience.

Science News: Relative Sit-to-Stand Muscle Power Predicts an Older Adult's Physical Independence at Age of 90 Yrs Beyond That of Relative Handgrip Strength, Physical Activity, and Sedentary Time: A Cross-sectional Analysis

Functional decline associated with advanced age results in significant morbidity and mortality, in addition to increased demand on healthcare systems. Models and testing to predict functional decline help healthcare systems direct resources to vulnerable individuals that are at risk of future loss of independence.

Science News: Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial

There has been growing evidence that patients with myasthenia gravis (MG) can benefit from Rituximab therapy, particularly patients with refractory disease or MuSK antibody positive MG. However, there is no standardized protocol and hence it is a third-line treatment option in AChR antibody positive MG.

Science News: Ultrasound of Cervical Nerve Root Enlargement in Polyneuropathy is not Confounded by Neuroforaminal Stenosis

In this study, the authors aimed to investigate whether neuroforaminal cervical stenosis is associated with cervical root enlargements detectable by ultrasound.

Science News: Amyotrophic Lateral Sclerosis and Noninvasive Positive Pressure Ventilatory Support: "Nasal Noninvasive Ventilation" or "Noninvasive Ventilatory Support"?

This article proposes a trial of noninvasive ventilatory support as an alternative to tracheostomy in patients with amyotrophic lateral sclerosis (ALS). Studies have shown brief statistical benefit of nasal noninvasive ventilation; however, this strategy may not be able to normalize carbon dioxide (CO2), leading to hypercapnia and therefore eventually to CO2 narcosis, intubation, and tracheostomy.