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AANEM News Express

Science News: Amyotrophic Lateral Sclerosis and Noninvasive Positive Pressure Ventilatory Support: "Nasal Noninvasive Ventilation" or "Noninvasive Ventilatory Support"?

    11/14/2022
This article proposes a trial of noninvasive ventilatory support as an alternative to tracheostomy in patients with amyotrophic lateral sclerosis (ALS). Studies have shown brief statistical benefit of nasal noninvasive ventilation; however, this strategy may not be able to normalize carbon dioxide (CO2), leading to hypercapnia and therefore eventually to CO2 narcosis, intubation, and tracheostomy.

Science News: Extensor Digitorum Brevis Bulk and Associations With Fibular Motor Nerve Conduction Amplitude

    10/31/2022
Prior studies demonstrate fibular compound motor action potential (CMAP) < 4.0 mV predicts impairment of ankle proprioceptive precision and increased fall risk. The authors posit that evaluation of extensor digitorum brevis (EDB) may present a simple surrogate for CMAP amplitude. This study aims to correlate physician evaluation of EDB muscle bulk with CMAP amplitude on nerve conduction study (NCS).

Science News: Eculizumab Versus Rituximab in Generalised Myasthenia Gravis

    10/17/2022
A small sub-group of myasthenia gravis (MG) patients is refractory to first-line immunosuppressive medications. Complement-targeted therapies are relatively new in neurological practice but gaining grounds in the landscape of MG management, particularly acetylcholine receptor antibody (AChR)-Ab positive cases.

Science News: Measurement of Excitation-Contraction Coupling Time in Critical Illness Myopathy

    10/3/2022
This study describes a novel electrophysiological method using an accelerometer to measure the excitation-contraction coupling of the soleus muscle for early diagnosis of critical illness myopathy (CIM).

Science News: Physiological Localization by Sensory and Motor Inching Studies and Structural Abnormalities Detected by Ultrasonographic Changes in Carpal Tunnel Syndrome

    9/13/2022
This is a cross-sectional study that investigated carpal tunnel syndrome (CTS) to determine correlation of electrophysiologically localized entrapment site using inching study with anatomic entrapment site identified by ultrasound (US).

Science News: Decrease in Serum Anti-MAG Autoantibodies Is Associated With Therapy Response in Patients With Anti-MAG Neuropathy: Retrospective Study

    8/31/2022
This retrospective analysis tested the hypothesis that changes in serum anti-myelin-associated glycoprotein (MAG) autoantibodies are associated with clinical response to immunotherapy in patients with anti-MAG neuropathy. The study evaluated relative change in anti-MAG immunoglobulin M (IgM) titers, paraprotein level or total IgM, before, during or post treatment.

Science News: Electrophysiological Study of the Tibial Nerve Across the Tarsal Tunnel in Distal Symmetric Diabetic Polyneuropathy

    8/18/2022
In this study, 124 consecutive patients with distal symmetric diabetic polyneuropathy diagnosed using the diabetic neuropathic index (DNI) were prospectively enrolled to investigate abnormalities of motor conduction in the tibial nerve across the tarsal tunnel.

Science News: Guillain-Barré Syndrome Following COVID-19 Vaccines: A Scoping Review

    8/4/2022
The association of Guillain-Barré syndrome (GBS) with COVID-19 vaccines has been unclear.
 
As part of postauthorization safety surveillance, the US Food and Drug Administration (FDA) has identified a potential safety concern for GBS following receipt of the COVID-19 vaccine.
 

Science News: Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis

    8/4/2022
This study evaluates the long-term safety and effectiveness of intravenous edaravone therapy for patients with ALS in a real-world clinical setting.

Science News: Comorbidities in Older Patients With Myasthenia Gravis - Comparison Between Early- and Late-Onset Disease

    7/22/2022
Based on the age of onset, myasthenia gravis (MG) is differentiated into early-onset (EOMG) and late-onset (LOMG). This study’s aim was to investigate comorbidities in the older population and compare EOMG and LOMG patients. The age of 50 is used as the cutoff to differentiate EOMG and LOMG.
 


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