AANEM News Express

AANEM News Express

Science News: Assessing Diagnostic and Severity Grading Accuracy of Ultrasound Measurements for Carpal Tunnel Syndrome Compared to Electrodiagnostics

    11/16/2021
Prospective study of 95, 18-80 y.o. patients referred for EDX of idiopathic CTS. Exclusion criteria for prior CTS and other concomitant confounding factors.  CSI performed and Bland criteria used to assess for severity.

Science News: Effect of High-Frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy: A Randomized Clinical Trial

    11/16/2021
Nevro's SENZA-PDN study, RCT of spinal cord stimulation treatment conducted for PDN-painful diabetic polyneuropathy, compares 10 kHz SCS plus Conventional Medical Management (CMM) to CMM alone in 216 patients at 18 centers in the United States.

Science News: Skeletal Muscle and Peripheral Nerve Histopathology in COVID-19

    11/4/2021
This study discusses spectrum of skeletal muscle and nerve pathology of patients who died following SARS-CoV-2 infection.
Psoas muscle and femoral nerve sampled from 35 consecutive autopsies of patients who died following SARS-CoV-2 infection were collected and analyzed.
 

Science News: Impact of Coronavirus Disease 2019 in a French Cohort of Myasthenia Gravis

    11/4/2021
Among 3,558 patients with MG registered in the French database for rare disorders, 34 (0.96%) had COVID-19. The mean age at COVID-19 onset was 55.0 ± 19.9 years (mean MG duration: 8.5 ± 8.5 years). By the end of the study period, 28 patients recovered from COVID-19, 1 remained affected, and 5 died.

Science News: Childhood Amyotrophic Lateral Sclerosis Caused by Excess Sphingolipid Synthesis

    10/20/2021
ALS is a devastating disease with poorly understood underlying pathophysiology. This article describes a rare cause of the early onset of motor neuron disease in children due to mutation in SPLTC1, a subunit of the SPT (serine palmitoyltransferase).

Science News: Epidemiology and Natural History of Inclusion Body Myositis A 40-Year Population-Based Study

    10/20/2021
This study determines the prevalence and natural history of sporadic inclusion body myositis (sIBM) and tests the hypothesis that patients with sIBM have higher cancer or mortality rates than the general population. The study identified 20 patients (10 clinicopathologically defined, 9 clinically defined, and 1 probable) according to the ENMC criteria and 1 patient with all features of clinicopathologically defined sIBM except for symptom onset at <45 years of age. The prevalence of sIBM in 2010 was 18.20 per 100,000 people ≥50 years old.

Patient Safety: NM Complications of Immune Checkpoint Inhibitors

    10/6/2021
Immune checkpoint inhibitors (ICPI’s) are monoclonal antibodies that target the immune checkpoints programmed death 1 (PD1), programmed death ligand 1 (PDL-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on T cells and promote immune mediated destruction of cancer cells. They are used to treat a variety of cancers including breast, bladder, cervical, colon, lung cancer, Hodgkin’s lymphoma, melanoma, etc. ICPI treatment is associated with an array of immune related adverse events affecting many organ systems. Neurologic adverse events have also been reported.

Science News: Acute Flaccid Myelitis: Long-Term Outcomes Recorded in the CAPTURE Study Compared With Paediatric Transverse Myelitis

    10/6/2021
This is a prospective, multicenter, non-randomized, observational cohort study of children with myelitis seen at academic centers in North America. The study lasted 5 years and the length of follow-up was 1 year. Pediatric patients diagnosed with myelitis were eligible for enrollment in the study within 6 months of onset of symptoms. Patients were classified as transverse myelitis (TM) or the acute flaccid myelitis (AFM) variant based on clinical and radiographic findings.

Brian Wallach Receives AANEM Public Recognition Award

    10/6/2021
AANEM's Public Recognition Award is awarded to public figures, celebrities, or entities that have made extraordinary contributions toward increasing public awareness of muscle and nerve disorders. This year's recipient is Brian Wallach, founder of I AM ALS. Since I AM ALS was founded, it has built partnerships with more than 30 organizations, testified three times before Congress, pushed long-awaited FDA ALS clinical trial guidance, built a 100 member congressional caucus, and delivered more than $83 million worth of federal research funding for ALS.

Jeremy D.P. Bland, MB ChB, FRCP, Receives 2021 Distinguished Researcher Award

    9/23/2021
The Distinguished Researcher Award is characterized by a member who has made continuous significant contributions to clinical neurophysiological, NM, or MSK research. This year, this honor is awarded to Jeremy D.P. Bland, MB ChB, FRCP, a consultant in neurophysiology at East Kent Hospitals NHS Trust in Canterbury, United Kingdom. In addition, he is an honorary lecturer at King’s College in London.


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