AANEM Education News Express

AANEM News Express

Backward Walking Therapy for Diabetic Peripheral Neuropathy

    7/16/2014
Diabetic peripheral neuropathy is a common and costly condition, often leading to significant morbidity, including pain and foot ulcerations. A new study investigates the use of backward walking therapy as a treatment tool for patients with diabetic peripheral neuropathy.

Early Investigation of Novel ALS Treatment

    7/1/2014
A new learning phase study investigates a novel potential treatment for amyotrophic lateral sclerosis (ALS), the antibody Ozanezumab. It appears to be reasonably safe and worth proceeding with additional study.

Clinical Interpretation and Implications of Whole-Genome Sequencing

    5/20/2014
This JAMA article raises several key concerns about the NM physician’s ability to support the costs and effort required for whole-genome sequencing.

Is IVIg Therapy Warranted in Progressive Lower Motor Neuron Syndromes Without Conduction Block?

    5/6/2014
Study reports results of treatment of 31 consecutive patients with focal-onset lower motor neuron pattern limb weakness with intravenous immunoglobulin (IVIg). None of the patients had EDX signs of a generalized motor neuron disorder or evidence of conduction block.

Science News: Neurofascin IgG4 Antibodies in CIDP Associate With Disabling Tremor and Poor Response

    4/18/2014
CIDP is readily diagnosed by finding a combination of proximal and distal weakness, nerve conduction studies showing acquired demyelination, and albuminocytological dissociation. There are, however, no biomarkers that predict response to therapy reliably.

Urological Diagnoses Increased in Muscular Dystrophies

    4/9/2014
A muscular dystrophy study shows urologic dysfunction increases in more advanced stages of the disease and proposes possible associations between the frequency of urologic diagnoses and degree of inactivity, such as urine stasis, and with chronic exposure to medications such as corticosteroids.

New Insight Into the Pathogenesis of Axon Degeneration

    3/25/2014
Following injury to an axon, the segment distal to the lesion site undergoes Wallerian degeneration characterized by loss of the action potential, destruction of the cytoskeleton, membrane fragmentation, and demyelination. Axonal degeneration also occurs during neurodegenerative disorders.

A New Form of Prion Disease Causes Autonomic Neuropathy

    2/21/2014
Prion diseases are transmissible, sporadic, or inherited diseases usually associated with progressive dementia or ataxia and not with dysautonomia or peripheral neuropathy.

Muscle Histone Deacetylase 4 Upregulation in ALS

    12/17/2013
The typical course of ALS is rapidly progressive but in some patients the course is protracted with prolonged survival, sometimes for decades. Could the HDA gene be a potential target for therapeutic approaches to slow disease progression?

High-Dosage Ascorbic Acid Treatment in CMT Disease Type 1A

    12/9/2013
One of the largest randomized controlled trials of an intervention for patients with CMT. Earlier studies using lower doses of AA did not prove effective, but higher doses in mouse models improved both clinical and histological outcomes.


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