AANEM Education News Express

AANEM News Express

Science News - Atypical CIDP: Diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database

    1/10/2019
Submitted by: Francisco E. Gomez, MD 
Edited by: Niranjan N. Singh, MD


CIDP is one of the most common chronic demyelinating polyneuropathies encountered in clinical practice. Recently recognized atypical variants can be missed at onset and constitute around 20% of the cases at presentation. Recognizing them at the onset and treating as typical CIDP is important as they cause similar disability and delay in treatment may lead to permanent damage. This article provides knowledge of a different phenotype of CIDP and treatment response. 

Science News: Independent Home Use of a Brain-Computer Interface by People with Amyotrophic Lateral Sclerosis

    1/4/2019
Submitted by: Bryan DeSouza, MD
Edited by: Rocio Carolina Garcia Santibanez, MD


The Brain-Computer Interfaces (BCIs) are the next level in scientific and technological breakthroughs as neuromuscular specialists manage the devastating consequences of diseases like ALS. This article is a pivotal clinical trial that shows BCIs can provide a new practical method of restoring communication and control to people with severe neuromuscular disabilities. 

Science News: Ulnar Neuropathy With Abnormal Non-Localizing Electrophysiology: Clinical, Electrophysiological and Ultrasound Findings

    12/13/2018
Submitted by: Elliot Bodofsky, MD
Edited by: Rocio Carolina Garcia Santibanez, MD


Ulnar neuropathy is a common referral for electrodiagnostic studies. When the ulnar neuropathy is non-localizable, ultrasound can frequently aid in the diagnosis. Read more in the latest article summary from the News Science Editorial Board. 

Science News: Nerve Ultrasound Normal Values - Readjustment of the Ultrasound Pattern Sum Score UPSS

    12/6/2018
Submitted by: Elliot Bodofsky, MD
Edited by: Rocio Carolina Garcia Santibanez, MD


The News Science Editorial Board has chosen to highlight this article because ultrasound of nerves and muscles is a rapidly expanding area, leading to improvements in diagnosis of nerve and muscle disease. Reliable normal values, adjusted for gender, age, height and weight as appropriate are crucial. 

Science News: Female Dystrophinopathy: Review of the Current Literature

    11/13/2018
Submitted by Benn E. Smith, MD, News Science Editorial Board
Edited by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board


Those who care for muscular dystrophy patients will find this article – Female Dystrophinopathy: A Review of the Current Literature – a valuable resource as they continue to care for not only the more common population of boys and young men with Duchenne muscular dystrophy, but also for their sisters, mothers, and other female relatives.

Science News: Eteplirsen Treatment for Duchenne Muscular Dystrophy: Exon Skipping and Dystrophin Production

    10/30/2018
Submitted and edited by Leigh Maria K. Ramos-Platt, MD

While questions remain regarding whether increased dystrophin expression results in increased strength, this study demonstrates that Eteplirsen increases dystrophin production.

Science News: Anti-HMGCR Myopathy

    10/16/2018
Submitted by Benn E. Smith, MD, News Science Editorial Board
Edited by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board


This paper provides a succinct overview of anti-HMGCR myopathy, a readily diagnosable autoimmune necrotizing myopathy which can mimic LGMD.

Science News: Individualized Immunoglobulin Therapy in Chronic Immune-Mediated Peripheral Neuropathies

    10/2/2018
Submitted by Benn E. Smith, MD, News Science Editorial Board
Edited by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board


This article is recommended by the AANEM News Science Editorial Board due to its clear presentation of IVIg immunology, biology, and pharmacokinetics. It discusses the well-known “wearing off” phenomenon as well as a recommended algorithm to be used to adjust frequency and dose adjustments. 

September 30 is Limb Girdle Muscular Dystrophy Awareness Day!

    9/30/2018
AANEM is pleased to play a role in helping to increase understanding about Limb Girdle muscular dystrophy (LGMD) on LGMD Awareness Day (September 30, 2018)! View AANEM resources to help you learn more about this disease. 

Science News: Muscular and Extramuscular Clinical Features of Patients with Anti-PM/Scl Autoantibodies

    9/18/2018
Submitted by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board
Edited by Benn E. Smith, MD, News Science Editorial Board


This study focuses on whether there were features which set anti-PM/Scl autoantibody positive myositis patients apart from those patients with the 3 most common myositis (Dermatomyositis, Antisynthetase Syndrome, and Immune Mediated Necrotizing Myopathy). Using data from the John Hopkins Myositis Center Longitudinal Cohort collected between 2002 and 2016, various clinical and diagnostic study parameters found that there were differences which set these patients apart. 


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