AANEM Education News Express

AANEM News Express

Science News: High Prevalence of Neutralizing Antibodies After Long-term Botulinum Neurotoxin Therapy

Submitted by: Bryan X. DeSouza, MD
Edited by: Hristelina Ilieva, MD, PhD

The News Science Editorial Board has chosen this article to share because it identifies a higher than expected risk of immunogenicity from therapeutic toxins, which may cause secondary treatment failures. Knowing that the development of neutralizing antibodies to botulinum toxin increases with the duration of treatment and dose will guide therapeutic decisions to optimize outcomes and lower failure rates. 

Science News: Prospective Evaluation of the Incidence and Persistence of Gestational Carpal Tunnel Syndrome

Submitted by: Lisa M. Williams, MD
Edited by: Bryan DeSouza, MD

Carpal tunnel syndrome (CTS) is one of the most common referrals for NM and EDX medicine. The News Science Editorial Board chose this article to highlight because it is a large scale prospective study identifying the incidence and risk factors for gestational CTS (GCTS). GCTS is a poorly understood complication of pregnancy. As NM specialists, understanding this common problem of pregnancy and the related risk factors will be important for diagnosis, management and successful outcomes.

Science News: Peripheral Nerve Regeneration Using a Bio 3D Conduit from Undifferentiated Bone Marrow Stromal Cells

Submitted by: Lisa M. Williams, MD
Edited by: Bryan DeSouza, MD

The repair and regeneration of peripheral nerves and restoration of function in nerve injuries has been has been an active but complex area of research for many years. Neurotrophic factors such as recombinant human nerve growth factor (rh-NGF) have been evaluated in clinical trials, but had mixed results. Currently, there is a growing area of interest in combining stem cells with hybrid biological technology to evaluate the utility in nerve repair and regeneration. This article is an important first step in evaluating the safety and efficacy of these new hybrid biological technologies as they apply to NM and EDX medicine.

Science News: Low Sensitivity of Skin Biopsy in Diagnosing Small Fiber Neuropathy in Chinese Americans

Submitted by: T. Darrell Thomas, MD 
Edited by: Bryan DeSouza, MD

Small fiber sensory neuropathy (SFSN) is a common referral for NM and EDX medicine. The use of skin biopsy to measure the intraepidermal nerve fiber density (IENFD) is widely accepted as a standard diagnostic test for SFSN; however, the normative values have not been fully established in diverse patient populations. This article is important in practice because it provides evidence that IENFD may vary in different patient populations. This information will affect the diagnosis, management and outcomes if ethnic differences are not accounted for in the interpretation of data.

Science News: A Novel Autoantibody Against Plexin D1 in Patients with Neuropathic Pain

Submitted by: Clark Pinyan, MD, MPH
Edited by: Bryan DeSouza, MD

Neuropathic pain is a common presenting complaint in neuromuscular diseases. The News Science Editorial Board believe this article is important because it provides evidence that an autoimmune inflammatory response may play a role in the pathogenesis of peripheral neuropathic pain. Moreover, in 10% of patients with neuropathic pain autoantibodies to a specific antigen on unmyelinated C-fiber type dorsal root neurons. 

Science News: Randomized Double-blinded Clinical Trial of 5% Dextrose Versus Triamcinolone Injection for Carpal Tunnel Syndrome Patients

Submitted by: Clark W. Pinyan, MD, MPH 
Edited by: Niranjan N. Singh, MD

Carpal tunnel syndrome is a common and disabling condition seen in clinical practice by both physiatrists and neurologists. Diagnosis is easy, but the treatment is difficult. Knowledge of this new treatment option will help physicians select the best treatment for the patient.

Science News: Targeted Neurotechnology Restores Walking in Humans With Spinal Cord Injury

Submitted by: Hristelina Ilieva, MD, PhD
Edited by: Niranjan N. Singh, MD

Patients with spinal cord injuries are seen in clinical practice by both neurologists and physiatrists. Knowledge of the technological framework for improving neurological recovery in patients who have failed traditional rehabilitation methods is very important for both patients and physicians. It’s important for treating physicians to be aware of this breakthrough neurotechnology discovery to help restore walking in humans with spinal cord injury.