AANEM News Express Related to Science News

AANEM News Express

Science News: Muscular and Extramuscular Clinical Features of Patients with Anti-PM/Scl Autoantibodies

    9/18/2018
Submitted by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board
Edited by Benn E. Smith, MD, News Science Editorial Board


This study focuses on whether there were features which set anti-PM/Scl autoantibody positive myositis patients apart from those patients with the 3 most common myositis (Dermatomyositis, Antisynthetase Syndrome, and Immune Mediated Necrotizing Myopathy). Using data from the John Hopkins Myositis Center Longitudinal Cohort collected between 2002 and 2016, various clinical and diagnostic study parameters found that there were differences which set these patients apart. 

Science News: Safety and Efficacy of Eculizumab in Guillain-Barré Syndrome: A Multicentre, Double-blind, Randomised Phase 2 Trial

    9/5/2018
Submitted by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board
Edited by Benn E. Smith, MD, News Science Editorial Board


Eculizumab is an anti-C5 humanized monoclonal antibody. Misawa et al report on a 34 patient, 24-week double-blind, randomized phase 2 study comparing IVIG and 4 weeks of eculizumab (900 mg per dose) versus IVIG and 4 weeks of placebo.

Science News - Muscle MRI in Patients with Dysferlinopathy: Pattern Recognition and Implications for Clinical Trials

    8/22/2018
Submitted by Francisco E. Gomez, MD, News Science Editorial Board 
Edited by Benn E. Smith, MD, News Science Editorial Board


This article summarizes a research paper in which the authors sought to describe the pattern and natural history of muscle involvement in patients with dysferlinopathies via MRI studies. 

Science News: Three Article Summaries on Recent Amyotrophic Lateral Sclerosis (ALS) Research Findings

    8/8/2018
The AANEM News Science Editorial Board provides summaries of recent research articles related to ALS.
  • Serum neurofilament light chain levels as a marker of upper motor neuron degeneration in patients with amyotrophic lateral sclerosis.
  • Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis
  • Electromyography study of the thoracic paraspinal and rectus abdominis muscles in amyotrophic lateral sclerosis

Science News: Ultrasonography of the Transverse Movement and Deformation of the Median Nerve and its Relationships with Electrophysiological Severity in the Early Stages of Carpal Tunnel Syndrome

    6/20/2018
Submitted by Lisa M. Williams, MD, News Science Editorial Board

To date, conflicting theories behind the initial pathogenic mechanism of carpal tunnel syndrome (CTS) exist. Recently, researchers have investigated the transverse plane movement of the median nerve as a potential mechanism for CTS. Using ultrasonography, the researchers of this study designed a cross-sectional, case-controlled study measuring deformation and displacement of the median nerve as it related to severity of CTS confirmed by electrophysiological studies. 

Science News: Clustering of Neuropsychiatric Disease in First-degree and Second-degree Relatives of Patients with Amyotrophic Lateral Sclerosis

    6/13/2018
Submitted by Niranjan N. Singh, MD, News Science Editorial Board

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition primarily involving the motor system. There is increasing epidemiologic evidence of an association between ALS and a wider spectrum of neurodegenerative and neuropsychiatric disorders among family members, including schizophrenia and psychotic illness and suicidal behavior. In this issue of JAMA Neurology, O’Brien et al present a case-control family aggregation study of genetic pleiotropy within ALS kindreds.

Science News: Effect of Fascia Penetration on Sensory Nerve Conduction in the Superficial Radial Nerve

    6/7/2018
Submitted by Rocio Carolina Garcia Santibanez, MD, News Science Editorial Board

In this study, the investigators sought to determine the effect of the fascia penetration of the radial nerve in its sensory nerve action potential amplitude.

Science News: Motor Performance Deterioration Accelerates After 50 Years of Age in Charcot-Marie-Tooth Type 1A Patients

    5/31/2018
Submitted by Nandita S. Keole, MD, News Science Editorial Board

The aim of this study was to describe, by a case control and cross-sectional design, the correlation between clinical impairment and age in Charcot-Marie-Tooth type 1A (CMT1A) patients.

Science News - Diagnosis and Management of SMA Part 1: Recommendations for Diagnosis, Rehabilitation, Orthopedic, and Nutritional Care

    5/25/2018
Submitted by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board   
Additional comments by David B. Rosenfield, MD, News Science Editorial Board


In December 2016, the spinal muscular atrophy (SMA) community recognized the need for the SMA Standards of Care (SOC) document to be updated. Part 1 of the updated set of guidelines was recently published and this summary highlights those updates. 

Science News: Nusinersen Versus Sham Control in Later-onset Spinal Muscular Atrophy

    5/15/2018
Submitted by David R. Mayans, MD, News Science Editorial Board  
Additional comments by David B. Rosenfield, MD, News Science Editorial Board


This is another study adding to the growing body of evidence that Nusinersen is effective at not only slowing the progression of SMA, but leading to improvements in strength and gain of function in SMA patients. 


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