AANEM News Express

AANEM News Express

Positive Effects of Bisphosphonates on Bone and Muscle in a Mouse Model of Duchenne Muscular Dystrophy

6/29/2016
 
Yoon S, Sugamori, KS, Grynpas MD, Mitchell D. Positive Effects of Bisphosphonates on Bone and Muscle in a Mouse Model of Duchenne Muscular Dystrophy. Neuromusc Dis 2016;26:73–84. nition and Management of Acute Flaccid Myelitis in Children. Nelson, GR et al. Pediatric Neurology 55(2016) 17-21.

Submitted by Kathya Ramos, MD, News Science Editorial Board

Patients with Duchenne muscular dystrophy (DMD) are at risk for reduced bone mineral density and fracture secondary to inactivity.  To determine if antiresorptive bisphosphonates could improve bone quality and muscle health, the authors studied Mdx mice treated with pamidronate during peak bone growth. Twenty mice were randomly assigned into bisphosphonate (BP) and untreated control groups. At 5 and 6 weeks of age, BP mice received pamidronate 2 mg/kg twice per week. At 13 weeks, the BP mice showed increased cortical bone density, femur strength, and fracture resistance in long bones but not in vertebral bodies. Pamidronate treatment also had positive effects on muscle: serum creatine kinase was reduced, muscle histology was improved, and grip strength was increased. Diaphragm function, however, did not improve.
 
Comment: This study supports a possible beneficial effect of pamidronate on bone and muscle health in the Mdx mouse. The improvement in bone density is consistent with previous retrospective work in human subjects. The identification of improved muscle structure and function with pamidronate is a novel finding that will require reproduction and further exploration.

About the AANEM News Science Editorial Board
The board helps to highlight significant, timely science news items for AANEM members. It reviews articles in journals and websites, identifies newsworthy items in the field, and writes article summaries.


View Related News Stories:

  Practice


Recent AANEM News

Recap: 2019 AMA House of Delegates Annual Meeting

Science News: Efficacy of Botulinum Toxin A for Treating Cramps in Diabetic Neuropathy

Science News: Diagnostic Sensitivity of Electrophysiology and Ultrasonography in Ulnar Neuropathies of Different Severity

Science News: Long-term Effect of Thymectomy Plus Prednisone Versus Prednisone Alone in Patients with Non-thymomatous Myasthenia Gravis: 2-year Extension of the MGTX Randomised Trial

AANEM Returns to Capitol for 6th Annual Hill Day





Advertisement

TPP

Advertisement

ABEM

Advertisement

Find Your Dream Job