AANEM News Express

AANEM News Express

Science News: Smoking and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study

10/4/2019
 
Submitted by Clark Pinyan, MD
Edited by Nandita Keole, MD


Smoking and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study. Zhang Y, Fang F. Ann. Neurol 2019;85:482-484


Authors examined the potential causal effect of smoking on ALS using Mendelian randomization method. Genome-wide association study data was reviewed for loci associated with smoking (current or ever smoked ). Over 500,000 total participants study data was compared with genomic data from over 12,000 patients with ALS. Based on this method, smokers were found to have a higher risk of ALS compared with non-smokers and provides (further) evidence for a causal relationship.


Genome linkage studies use genetic markers associated with a risk (such as tendency to smoke, cancer, or hypercholesterolemia), compared with incidence of a particular condition, in this case ALS. This can overcome some limitations of traditional epidemiology such as recall or selection bias, by being independent of patient self-reporting or selection. Furthermore, Mendelian randomization can suggest a causative link if certain conditions are met.


In this study, ever smokers were found to have a higher risk of ALS compared to never smokers, which provides further support for more traditional epidemiological studies.


Comments: Epidemiological studies of ALS can be limited by the sometimes rapid progression of the disease, and this provides information on use of new methods of risk analysis. I think it will become increasingly important to understand how to use whole genomic data to determine risk, not only for researchers but soon for clinicians.



View Related News Stories:

  EducationScience News


Recent AANEM News

Resources for Small Practices During COVID-19

Science News: Imaging of the Peripheral Nerve: Concepts and Future Direction of Magnetic Resonance Neurography and Ultrasound

Science News: Treadmill Training in Patients Affected by Charcot-Marie-Tooth Neuropathy: Results of a Multicenter, Prospective, Randomized, Single-blind, Controlled Study

Registration for ABEM's 2020 Neuromuscular Ultrasound Certificate of Added Qualification (CAQ) Exam is Open

Science News: Combined Intravenous Immunoglobulin and Methylprednisolone as Induction Treatment in Chronic Inflammatory Demyelinating Polyneuropathy (OPTIC protocol): A Prospective Pilot Study





Advertisement

ABEM

Advertisement

TPP

Advertisement

Devon products