AANEM News Express

AANEM News Express

Science News: Serum Neurofilament Light Chain Predicts Long-Term Prognosis in Guillain-Barré Syndrome Patients

2/17/2021
 
NSEB.jpgSubmitted by: Francisco Gomez, MD
Edited by: Elliot Bodofsky, MD

Martín-Aguilar L, Camps-Renom P, Lleixà C, Pascual-Goñi E, Díaz-Manera J, Rojas-García R, Querol L. Serum neurofilament light chain predicts long-term prognosis in Guillain-Barré syndrome patients. Journal of Neurology, Neurosurgery & Psychiatry. 2020. 323899. doi:10.1136.

Summary: 

This is presented by the International GBS Outcome Study (IGOS), based in Spain. The neurofilament light (NfL) chain is an increasingly studied biomarker for axonal injury, previously studied in Guillain-Barré syndrome (GBS). This study evaluates it as a prognostic maker in GBS. Enrolling 98 patients in 11 centers, the authors measured serum NfL (sNfl) in 98 patients vs 53 healthy controls. They performed a multivariable regression to correlate sNfL levels with functional outcome at one year.


GBS had higher serum NfL levels (55.49 pg/mL vs 9.83 pg/mL, p<0.0001) and CSF (1308.5 pg/mL vs 440.24 pg/mL, p=0.034) than controls. Patients with preceding diarrhea had higher sNfL than patients with respiratory symptoms or no prior infectious symptoms (134.90 pg/mL vs 47.86 pg/mL vs 38.02 pg/mL, p=0.016). Patients with pure motor variant and Miller Fisher syndrome showed higher sNfL levels than patients with sensorimotor GBS (162.18 pg/mL vs 95.50 pg/mL vs 38.02 pg/mL, p=0.025). Patients with AMAN had higher sNfL levels than other variants (190.55 pg/mL vs 46.79 pg/mL, p=0.013). sNfL returned to normal levels at 1 year. High baseline sNfL levels were associated with inability to run (OR=1.65, 95% CI 1.14 to 2.40, p=0.009) and lower I-RODS (β −2.60, 95% CI −4.66 to −0.54, p=0.014) at 1 year. Cut-off points predicting clinically relevant outcomes at 1 year with high specificity were calculated: inability to walk independently (>319 pg/mL), inability to run (>248 pg/mL) and ability to run (<34 pg/mL).
 

Comments: An interesting article further wading into the field of biomarkers in neurology. While not necessarily validated or widely applicable, it breaks new ground in the field of GBS neuroprognostication.


View Related News Stories:

  EducationScience News NSEB


Recent AANEM News

Remembering George Kraft, MD, MS

The American Clinical Neurophysiology Society to Hold Another Townhall Meeting of Clinical Neurophysiology, Epilepsy, and Neuromuscular Fellowship Program Directors

Science News: Amyotrophic Lateral Sclerosis and Noninvasive Positive Pressure Ventilatory Support: "Nasal Noninvasive Ventilation" or "Noninvasive Ventilatory Support"?

CMS Finalizes Updates to Physician Fee Schedule

Advocacy in Action: State Liaison Leads the Way for Patient Advocacy in Washington and Beyond





Advertisement

ABEM

Advertisement

Donate

Advertisement