AANEM News Express

AANEM News Express

Science News: Peripheral Nerve Regeneration Using a Bio 3D Conduit from Undifferentiated Bone Marrow Stromal Cells

2/14/2019
 
Submitted by: Lisa M. Williams, MD
Edited by: Bryan DeSouza, MD


Yurie H, Ikeguchi R, Ohta S, Oda H, Takeuchi H, Matsuda S. Peripheral nerve regeneration using a bio 3D conduit from undifferentiated bone marrow stromal cells. The Journal of Hand Surgery. 2018. doi: 10.1016/j.jhsa.2018.06.074

The reference standard for nerve regeneration includes use of autologous nerve grafting. However, biocompatitibility is low and risk of infection is a concern. To address this issue, a 3D biologic conduit using undifferentiated bone marrow stromal cells (uBMSCs) to promote peripheral nerve regeneration in peripheral nerve injuries involving a nerve gap were studied. Efficacy of this new technique was compared to previously studied fibroblast conduits.   

In this study, primary uBMSCs were isolated from femoral bone marrow of Lewis rats. Fibroblasts were harvested from subcutaneous skin tissue. Conduits were made from both cells using a bio 3D printer and interposed onto rat sciatic nerves spanning a 5mm nerve gap. Electrophysiolgic studies showed significantly higher compound muscle action potential (CMAP) amplitude (p<.05) in rat adductor muscles using uBMSCs and a greater amount of myelinating axons were noted in the uBMSC (p<0.5).

Comment: Biologic regeneration techniques targeting peripheral nerve injuries are an emerging area of research. More studies are needed to evaluate the safety and efficacy in humans.


View Related News Stories:

  EducationScience News


Recent AANEM News

Muscle & Nerve Reveals Top 5 Downloaded Articles of 2019

Science News: Degree of Agreement between Electrodiagnostic Testing and Magnetic Resonance Imaging in the Evaluation of Brachial Plexopathy

AANEM Calls For Research in Neuromuscular/Electrodiagnostic Medicine

AANEM Seeking Early Career Speaker to Receive the 2020 Surinderjit Singh Young Lectureship Award

Science News: Muscle and Not Neuronal Biomarkers Correlate With Severity in Spinal and Bulbar Muscular Atrophy





Advertisement

ABEM

Advertisement

TPP

Advertisement

Ultra EMG