Submitted by Nandita Keole, MD
Antidiabetics, Statins, and the Risk of Amyotrophic Lateral Sclerosis (ALS)
Mariosa D, Kamel F, Bellocco R, et al. Eur J Neurol
. 2020;27(6):1010-1016. doi:10.1111/ene.14190
Drugs used to treat glucose or lipid metabolism have been suggested as risk factors for ALS.
Population based case control study ( 5 controls for each case of ALS) done in Sweden to examine the association between statins ,antidiabetics and subsequent development of ALS. Study examined cases from July 2006 to Dec. 2013 from national database . Prescriptions filled for years prior to diagnoses was examined using a national prescription database. They found that patients with ALS were less likely to have been prescribed antidiabetics and there was no association with statins overall though in women statins were prescribed the year before diagnoses of ALS. This per authors may point to a risk of accelerated course of ALS in patients who have been prescribed statins.
This study suggested that antidiabetics have a protective effect for ALS- could prove a pathway for treatment or risk mitigation.