Submitted by Benn E. Smith, MD, News Science Editorial Board
Edited by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board
Mohassel P, et al. Anti-HMGCR myopathy
. J Neuromusc Dis
In the May 2018 issue of Journal of Neuromuscular Diseases
, Payam Mohassel and Andrew Mammen from NIH present a timely review of Anti-HMGCR Myopathy.
The review surveys multiple aspects of the disorder:
- Historical context
- Clinicopathologic spectrum
- Anti-HMGCR autoantibody testing
- Pathophysiology and mechanism of disease
This paper provides a succinct overview of anti-HMGCR myopathy, a readily diagnosable autoimmune necrotizing myopathy which can mimic LGMD. Although the vast majority have a history of statin exposure a number are statin-naïve. This publication will be useful to those caring for myopathy patients.