AANEM News Express

AANEM News Express

Science News: Anti-HMGCR Myopathy

10/16/2018
 
Submitted by Benn E. Smith, MD, News Science Editorial Board
Edited by Leigh Maria K. Ramos-Platt, MD, News Science Editorial Board


Mohassel P, et al. Anti-HMGCR myopathy. J Neuromusc Dis 2018;5:11-20.

In the May 2018 issue of Journal of Neuromuscular Diseases, Payam Mohassel and Andrew Mammen from NIH present a timely review of Anti-HMGCR Myopathy.

The review surveys multiple aspects of the disorder:
  1. Historical context
  2. Clinicopathologic spectrum
  3. Anti-HMGCR autoantibody testing
  4. Treatment
  5. Pathophysiology and mechanism of disease
Comment: This paper provides a succinct overview of anti-HMGCR myopathy, a readily diagnosable autoimmune necrotizing myopathy which can mimic LGMD. Although the vast majority have a history of statin exposure a number are statin-naïve. This publication will be useful to those caring for myopathy patients.


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