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Physician Podcasts

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Exome Sequencing by Michael Shy, MD and Stephan Zuchner, MD

    3/10/2014
Exome sequencing discussion by Michael Shy, MD and Stephan Zuchner, MD, interviewed by Ted Burns, MD.

Spinal muscular atrophy: development and implementation of potential treatments

    12/19/2013
Spinal muscular atrophy: development and implementation of potential treatments by Drs. David Arnold and Arthur Burghes. Ann Neurol. 2013 Sep;74(3):348-62. doi: 10.1002/ana.23995. This podcast is a brief discussion of the article in Annals in Neurology. The article discusses the rapid progress in the understanding of recessive proximal spinal muscular atrophy and how this is leading to exciting potential treatments of the disease. Spinal muscular atrophy is caused by loss of the survival motor neuron 1 (SMN1) gene and reduced levels of SMN protein. The critical downstream targets of SMN deficiency that result in motor neuron loss are not known. However, increasing SMN levels has a marked impact in mouse models, and these therapeutics are rapidly moving toward clinical trials. Promising preclinical therapies, the varying degree of impact on the mouse models, and potential measures of treatment effect are reviewed. One key issue discussed is the variable outcome of increasing SMN at different stages of disease progression.

Amyotrophic lateral sclerosis and palliative care: Where we are, and the road ahead by Dr. Blackhall

    11/21/2013
Amyotrophic lateral sclerosis and palliative care: Where we are, and the road ahead by Dr. Leslie J. Blackhall, interviewed by Dr. Michael K. Hehir. Patients with amyotrophic lateral sclerosis (ALS) have high symptom burdens, including pain, fatigue, dyspnea, and sialorrhea, and they must make difficult decisions about the use of life-prolonging therapies, such as long-term mechanical ventilation. The impact of ALS is also felt by family caregivers who often struggle to meet the heavy physical, financial, and emotional demands associated with the illness. Expert multidisciplinary care may improve both quality and length of life of patients with ALS. However, although advances have been made in the treatment of some symptoms, others, including pain management, remain poorly studied. Involvement of palliative care specialists as part of the ALS multidisciplinary team is recommended, as we continue to work toward improving the quality of life for patients and their families. Muscle Nerve, 2012. The ideas and opinions expressed are solely those of the specific authors and do not necessarily represent those of AANEM.

Myasthenia Gravis and the use of IVIg and Therapeutic Plasma Exchange by Dr. Vern Juel

    8/30/2013
Dr. Elliot Dimberg interviews Dr. Vern Juel regarding the treatment of myasthenia gravis. Specifically, they discuss the use of intravenous immune globulin and plasma exchange. They present the indications, differences in use, and differences in risk between the two treatments, as well as differences between peripheral and central access.

Inherited Neuropathies: Clinical Overview and Update

    7/30/2013
Inherited Neuropathies: Clinical Overview and Update by Drs. Christopher Klein and Michael Shy interviewed by Dr. Laurie Gutmann. Muscle Nerve. 2013 Jan 30. doi: 10.1002/mus.23775

Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis by Dr.Steven Greenberg

    6/5/2013
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis by Dr. Steven A. Greenberg interviewed by Dr. Ted Burns. Ann Neurol. 2013 Mar;73(3):408-18. doi: 10.1002/ana.23840.

Diagnostic Ultrasound of the Fibular (Peroneal) Nerve

    5/8/2013
Diagnostic Ultrasound of the Fibular (Peroneal) Nerve interviewed by Dr. Ted Burns.

Diagnostic Ultrasound of the Ulnar Nerve and Ulnar Neuropathy at the Elbow

    4/19/2013
Diagnostic Ultrasound of the Ulnar Nerve and Ulnar Neuropathy at the Elbow by Drs. Francis Walker and Michael Cartwright interviewed by Dr. Ted Burns.

Diagnostic Ultrasound of the Median Nerve and Median Neuropathy at the Wrist

    3/27/2013
Diagnostic Ultrasound of the Median Nerve and Median Neuropathy at the Wrist by Drs. Francis Walker and Michael Cartwright interviewed by Dr. Ted Burns.

Facioscapulohumeral muscular dystrophy: molecular pathological advances and future directions

    2/22/2013
Facioscapulohumeral muscular dystrophy: molecular pathological advances and future directions by Drs. Jeff Statland and Rabi Tawil, interviewed by Dr. Ted Burns. Article published in Curr Opin Neurol. 2011 Oct;24(5):423-8. doi: 10.1097/WCO.0b013e32834959af

Paraneoplastic Neuromuscular Disorders by Drs. Lydia Sharp and Steven Vernino

    12/28/2012
Paraneoplastic Neuromuscular Disorders by Drs. Lydia Sharp and Steven Vernino, interviewed by Dr. Ted Burns, Muscle Nerve. 2012 Dec;46(6):839-40. doi: 10.1002/mus.23502.

Diabetic cervical radiculoplexus neuropathy: a distinct syndrome expanding the spectrum of diabetic radiculoplexus neuropathies

    11/29/2012
Diabetic cervical radiculoplexus neuropathy: a distinct syndrome expanding the spectrum of diabetic radiculoplexus neuropathies by Drs. P. J. Dyck and R. Massie, interviewed by Dr. Ted Burns. Brain. 2012 Oct;135(Pt 10):3074-88. doi: 10.1093/brain/aws244.

Chronic pain as a manifestation of potassium channel-complex autoimmunity by Dr. Christopher Klein

    10/23/2012
Chronic pain as a manifestation of potassium channel-complex autoimmunity by Dr. Christopher Klein, interviewed by Dr. Ted Burns. Neurology. 2012;79:1136-44. Epub 2012 Aug 15.

Diagnosis of the Limb-girdle Muscular Dystrophies

    8/29/2012
An interview with Dr. Kate Busby about diagnosis of the limb-girdle muscular dystrophies. Interviewed by Dr. Elliot Dimberg.

The Thoracic Outlet Syndromes by Dr. Mark A. Ferrante

    7/17/2012
An interview with Dr. Mark A. Ferrante about the article The Thoracic Outlet Syndromes in Muscle Nerve. 2012;45:780-95. Interviewed by Dr. Ted Burns.

The Role of Exercise in Amyotrophic Lateral Sclerosis by Amy Chen

    4/30/2012
An interview with Dr. Amy Chen about Chen A, Montes J, and Mitsumoto H. The Role of Exercise in Amyotrophic Lateral Sclerosis. Phys Med Rehabil Clin N Am. 2008;19:545-57, ix-x. Interviewed by Dr. Ted Burns.

The Distal Hereditary Motor Neuropathies by Dr. Mary Reilly

    3/27/2012
An interview with Dr. Mary Reilly about the article The distal hereditary motor neuropathies in J Neurol Neurosurg Psychiatry. 2012 83:6-14. Interviewed by Dr. Ted Burns.

Myokymic and Neuromyotonic Discharges by Drs. Ludwig Gutmann, Jasper Daube, and Devon Rubin

    2/23/2012
Drs. Ted Burns, Ludwig Gutmann, Jasper Daube, and Devon Rubin discuss myokymic and neuromyotonic discharges.

Evidence Based Guideline on Treatment of Painful Diabetic Neuropathy by Vera Bril, MD

    12/30/2011
Drs. Ted Burns and Vera Bril discuss the article Evidence Based Guidelines on Painful Diabetic Neuropathy. Muscle Nerve. 2011;43:910-7.

Cardiomyopathies in Muscular Dystrophies by Christopher Spurney, MD

    10/26/2011
Drs. Ted Burns and Christopher Spurney discuss the article Cardiomyopathy of Duchenne muscular dystrophy: current understanding and future directions in Muscle Nerve 2011;44:8-19.

Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy by Christopher H. Gibbons, MD

    10/7/2011
Drs. Ted Burns and Chris Gibbons discuss the article Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy in Ann Neurol. 2010 Apr;67(4):534-41 by Gibbons CH, Freeman R.

ALS may be caused by impaired protein recycling and degradation

    8/26/2011
Dr. Teepu Siddique talks about his paper Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia, interviewed by Dr. Ted Burns.

Good Nutritional Control May Prevent Polyneuropathy After Bariatric Surgery

    7/21/2011
Drs. Ted Burns, Pariwat Thaisetthawatkul, and P. James Dyck discuss the article Good Nutrional Control May Prevent Polyneuropathy After Bariatric Surgery Muscle Nerve. 2010 Nov;42(5):709-14.

Charcot-Marie-Tooth Disease Subtypes and Genetic Testing Strategies by Michael Shy, MD

    6/16/2011
An interview by Dr. Ted Burns with Dr. Michael Shy about the article Charcot-Marie-Tooth disease subtypes and genetic testing strategies in Ann Neurol. 2011 Jan;69(1):22-33. doi: 10.1002/ana.22166.

Evaluation and management of foot drop by John D. Stewart, MBBS,MRCP(UK),FRCP

    4/15/2011
Ted M. Burns, MD, interviews John D. Stewart, MBBS,MRCP(UK),FRCP, on the evaluation and management of patients with foot drop. They discuss peroneal neuropathies, as well as L5 radiculopathies, lumbosacral plexopathies and proximal sciatic neuropathies.
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